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The NGF System and its interplay with endocannabinoid signalling, from peripheral sensory terminals to the brain: new targets for the development of next generation drugs for neuropathic pain

May 29-30, 2014 Pisa
Venue: Sala Azzurra, Palazzo della Carovana
Scuola Normale Superiore
Piazza dei Cavalieri, 7

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Meeting Minutes are available only for project partners here

 

AGENDA

Thursday, May 29th II workshop Bio@sns – Open to public“The NGF and endocannabinoid systems and pain: new therapeutic opportunities”
MORNING SESSION
9.30 – 9.40 Welcoming address
ANTONINO CATTANEO, Project Coordinator |Scuola Normale Superiore
9.40 – 10.10 Targeting the NGF system for pain treatment: challenges and opportunities
ANTONINO CATTANEO | Scuola Normale Superiore
10.10 – 10.40 A new TrkA mouse model to study pain
JUAN CARLOS AREVALO | University of Salamanca
10.40 – 11.10 Suffering without pain: Hereditary Sensory and Autonomic Neuropathies type IV and V
SIMONA CAPSONI | Scuola Normale Superiore
11.10 – 11. 40 COFFEE BREAK
11.40 – 12. 10 NGF and the first pain synapse
MARZIA MALCANGIO | King’s College London
12.10 – 12. 40 Nerve Growth Factor scales endocannabinoid signaling by regulating monoacylglycerol lipase turnover in developing cholinergic neurons
ERIK KEIMPEMA | Medical University of Vienna
12. 40 – 13. 10 Cortical endocannabinoid receptors-mediated signaling in physiological and neuropathic pain conditions
SILVIA MARINELLI | European Brain Research Institute
13.15 – 14. 45 LUNCH
AFTERNOON SESSION
14.45 – 15.15 p75NTR-Fc a novel and safe biological for the treatment of chronic pain
SIMON WESTBROOK | Levicept Ltd
15.15 – 15. 45 A structural approach to understanding the function of proNGF/NGF
ANNALISA PASTORE | King’s College London
15.45 – 16.15 COFFEE BREAK
16.15 – 16.45 Epigenetic mechanisms in the long lasting analgesic properties of drugs targeting the NGF system in chronic pain
MARA D’ONOFRIO | European Brain Research Institute
16.45 – 17.15 Technologies to study epigenetic mechanisms controlling neuropathic pain
ARMANDO FELSANI | GENOMNIA
17.15 END OF MEETING

 

 


Friday, May 30th
WORK PACKAGES SESSION – Closed doors session
Each Work Package leader presented his Work Package, explaining objectives, tasks, milestones and deliverables if present and enlightening the existing interlinking between activities (within WP and across WP where relevant) and possible critical points.
MORNING SESSION
9.00 – 9.30 WP1 Understanding the mechanism of NGF system regulation of NP and OA
Aahrus Universitaet (A. Cattaneo will substitute)
9.30 – 10.00 WP2 Understanding Endocannabinoid signalling in NPE.
Keimpema | Medical University of Vienna
10.00 – 10.30 WP3 Molecular mechanisms of HSAN IV and HSAN V neuropathies: Suffering without pain
S. Capsoni, A. Cattaneo | Scuola Normale Superiore
10.30 – 11.00 COFFEE BREAK
11.00 – 11.30 WP4 New targets for NP and OA: gene expression profiling and epigenetic regulation of NP and OA
A. Felsani| Genomnia
11.30 – 12.00 WP5 Controlling Pain
S. Marinelli, M. D’Onofrio | European Brain Research Institute
12.00 – 12.30 WP6 Safety issues related to antiNGF therapies
S. Westbrook | Levicept Ltd
12.30 – 13.15 WP7 Structure based optimization of lead drug candidates
A. Pastore | King’s College London
13.15 – 14.30 LUNCH
AFTERNOON SESSION
14.30 – 15.00 WP8 Identification of NP and OA biomarkers for patients stratification
J.C. Arevalo | University of Salamanca
15.00 – 15.30 WP9 Project Management and Dissemination
A.Cattaneo | Scuola Normale SuperioreConsortium Bodies appointment:

  • General Assembly (composed by one high level representative of each project partner)
  • Steering Committee (Coordinator and Work Package Leaders)

Discussion and proposal about the appointment of:

  • Ethical Committee (one member for each partner, plus external experts)
  • Industrial Property Committee (to be appointed by the Steering Committee among the specialist of IPR in the different organization involved in the Paincage Project)
15.30 – 16.00 COFFEE BREAK
16.00 – 17.00 OPEN DISCUSSION

END OF MEETING 17.00