The NGF System and its interplay with endocannabinoid signalling, from peripheral sensory terminals to the brain: new targets for the development of next generation drugs for neuropathic pain



“The NGF System and its interplay with endocannabinoid signaling: new targets for the development of next generation drugs for neuropathic pain”




Palazzo Corsini
Via della Lungara, 10 Roma

After one year and half of extensive research the Paincage team decided to hold the project’s mid-term conference, which represented a valid opportunity to get together and reflect on the results of their interim investigations and to give the industries and patient’s associations, that greatly supported the project from its very beginning, the opportunity of being updated about the first project outcomes and of discussing with the Paincage Principal Investigators on the project’s current process and first results.

On December 14th, a one day Workshop took place from 9:00 AM to 6:30 PM, open to the public and titled: The NGF System and its interplay with endocannabinoid signaling: new targets for the development of next generation drugs for neuropathic pain, while the day after it took place a working meeting for partners only.

The Meeting took place at the Accademia Nazionale dei Lincei, the oldest scientific academy worldwide, founded by Prince Federico Cesi in 1603, which included among its first members Galileo Galilei. The seat of the Lincei Academy is in Palazzo Corsini, one of the most beautiful historical buildings in Rome. Located in via della Lungara 10 – Rome, at the foot of Gianicolo hill, in the heart of old Trastevere, Palazzo Corsini was built in the 15th century by the Riario family and later (18th century) purchased by Cardinal Neri Maria Corsini, nephew of Pope Clement XII. In the 17th century the palace was also the residence of Queen Christina of Sweden.




Monday December 14th, 2015

Antonino Cattaneo
PAINCAGE Coordinator, Bio@SNS Laboratory of Biology, Scuola Normale Superiore

Session I: About pain

9:20 – 10:00 Giorgio Cruccu
Department of Neurology and Psychiatry, Sapienza University – Rome, Italy
Neuropathic pain in the clinics
10:00 – 10:30 Andrea Nistri
International School for Advanced Studies – Trieste, Italy
Ying and yang of trigeminal nociception: relevance to migraine pathophysiology
10:30-11:00 Flaminia Pavone
Insitute of Cell Biology and Neurobiology, National Research Council of Italy, CNR, Rome, Italy
“Sex differences in development and recovery from neuropathic pain: new evidence from glial cells”
11:00-11:30 Fabrizio Benedetti
Center for Hypoxia, Plateau Rosa Labs, Breuil-Cervinia, Italy, Zermatt, Switzerland and University of Turin Medical School, Neuroscience Dept, Turin, Italy
“Drugs and placebos: what’s the difference?”
11:30-11:50 COFFEE BREAK

Session II: Suffering without pain

11:50-12:20 Leonardo Fogassi
Neuroscience Department, University of Parma, Italy
“Mirror mechanisms in the brain and empathy for pain”
 12:20-12:50 Simona Capsoni
Bio@SNS Laboratory of Biology – Scuola Normale Superiore
“Congenital Insensitivity to Pain: lessons from the Nerve Growth Factor system”
 12:50-13:20 Irene Perini
Center for Social and Affective Neuroscience, Institute for Clinical and Experimental Medicine, Linköping University, Sweden
“Adaptive pain behavior: from healthy subjects to NGFB mutation carriers”
13:20-14:20 LUNCH

Session III: The EC system and pain

14.20-14:50 Roy Gray
GW Pharmaceuticals, Cambridge, UK
“Exploiting the Poly-Pharmacology of Phytocannabinoids” 
14.50-15:20 Giovanni Marsicano
INSERM Neuro Centre Magendie, Bordeaux, France
“Mitochondrial Cannabinoid CB1 receptors (mtCB1) in the brain: memory and pain”
 15.20-15:50 Tibor Harkany
Center for Brain Research, Medical University of Vienna, Austria
“NGF and Endocannabinoids: from single cells to the intact nervous system”
 15.50-16:10 COFFEE BREAK

Session IV: The NGF system and pain

 16.10-16:40 Antonino Cattaneo
Laboratory of Biology Bio@SNS, Scuola Normale Superiore, Italy
“The NGF system: towards a new generation of drugs for Chronic Pain”
 16:40-17:10 Juan Carlos Arevalo
Department of Cellular Biology and Pathology, University of Salamanca, Spain
“Ubiquitination as a crucial component in NGF-TrkA system for pain”
17:10-17:40 Simon Westbrook
Levicept Ltd, UK
“p75NTR against pain” Title to be defined
17:40-18:10 Anders Nikjaer
Department of Biomedicine, Aahrus University, Denmark
Sortilin and Pain










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