The NGF System and its interplay with endocannabinoid signalling, from peripheral sensory terminals to the brain: new targets for the development of next generation drugs for neuropathic pain

Meeting NGF2018

On June 23 to 26 2018, the Paincage partner Juan Carlos Arevalo (USAL) organized in Salamanca the international conference on Neurotrophic Factors, the international NGF meetings held every two years. This is the most important meeting worldwide on NGF and neurotrophins, a forum that periodically calls together the most eminent scholars and scientist in the field. In the meeting (, two out of nine sessions were dedicated to “Pain, Neurotrophic Factors and Therapies”, and different members of the Paincage consortium were invited speakers and presented their work to the wider community (  Silva Lisa (from Juan Carlos Arevalo lab at USAL), Anders Nikjaer (AU), Antonino Cattaneo (SNS), Simona Capsoni (SNS). Patrick Ernfors from Karolinska Institute in Stockholm reported results performed in collaboration with Tibor Harkany (MUW). In the meeting Mark Brown, the Clinical Leader of the Tanezumab anti NGF program at Pfizer, reported on the progress of anti NGF clinical trials, after the clinical holds by FDA. This meeting was a very good occasion to present some of the Paincage results to the most relevant scientific community.

LINK to the Web page of the meeting:


Poster presentation at conferences:


School of Brain Cells & Circuits “Camillo Golgi”, Erice (Italy), Nov 2016

A poster was presented by EBRI: Cerna R,  Fiori E, D’Onofrio M,Brandi R, Arisi I, Malerba F, La Regina F, Turturro S, Marinelli S, Vacca V, Pavone F, Cattaneo A, “Long lasting analgesic effect of anti-NGF and anti-TrkA antibodies in neuropathic pain model”

SfN “Society for Neuroscience Annual Meeting”, Nov 2016, San Diego,  USA

A poster was presented by EBRI on WP4 outcomes: D’Onofrio M, Fiori E, Brandi R, Arisi I, Malerba F, La Regina F, Cerna R, Turturro S, Marinelli S, Vacca V, Pavone F, Cattaneo A. “Targeting NGF and TrkA to control neuropathic pain: long lasting analgesic effect of anti-NGF and anti-TrkA antibodies in Chronic Constriction Injury mouse model”.

A poster was presented by KCL-USAL: Joao Sousa-Valente; Laura Calvo; Juan Carlos, Arevalo; Marzia Malcangio, “TrkA signalling is critical for the initiation of osteoarthritis pain in the monoiodoacetate model”

A poster  on HSAN V mice was presented by SNS on WP3 outcomes: G. Testa, L. Pancrazi, M. Ceci, C. Morelli, M. Fabbri, M. Costa, P. Heppenstall, A. Cattaneo, S. Capsoni. Phenotypic characterization of a mouse model of Hereditary Sensory and Autonomic Neuropathy type V: new central aspects of feeling pain. Abstract n. 525.10

Five poster presentations at the FENS Forum 2016, July 2-7, Copenhagen (D033, C101, C106, B101, B102)

Yokohama, Japan 16th World Congress on Pain, Sep 2016

Poster was presented by Ivan Arisi (EBRI). Arisi I, D’Onofrio M, Fiori E, Brandi R, Malerba F, La Regina F, Cerna R, Giordano M, Di Battista L, Turturro S, Marinelli S, Vacca V, Pavone F, Cattaneo A. “Targeting NGF and TrkA to control neuropathic pain: a transcriptomic and behavioural study on long lasting analgesic effect of anti-NGF and anti-TrkA antibodies in Chronic Constriction Injury mouse model”.

Poster on TrkAKI and OA pain presented at the 13th IASP Research symposium

The poster on “Behavioural and immunohistochemical characterisation of TrkA knock-in mice in the monoiodoacetate model of osteoarthritis” presented by the PAINCAGE partners Joao Sousa-Valente and Marzia Malcangio from the King’s College London and Laura Calvo and Juan Carlos Arevalo from the Universidad de Salamanca, won the first prize at the 13th IASP Research symposium:”Bridging the gaps between pain research and osteoarthritis research” – Stockholm, 17-19th September 2015.

A Poster was presented  by SNS on WP3 outcomesTesta G, Pancrazi L, Capsoni S, Costa M, Cattaneo A. “Towards an NGF-based therapy for Hereditary Sensory and Autonomic Neuropathies IV and V”. XVIII Convention Telethon, 9-11/03/2015, Riva del Garda (TN), Italy

Other Dissemination Activities

At next IASP in Boston Marzia Malcangio will give a talk based on on the PAICAGE data – Proposal Title: The role of NGF, immune cells and cytokines in arthritic pain 
Speaker(s) Marzia Malcangio, PhD – Professor of Neuropharmacology, King’s College London (Role: Session organizer); Camilla Svensson, PhD – Assistant Professor, Karolinska Institute (Role: Speaker): Hans-Georg Schaible, MD – Professor of Physiology, University of Jena (Role: Speaker)- Marzia Malcangio Talk Title will be: Role of mast cells in mediating NGF nociception in the MIA model

Oral Presentation: Anders Nykjær, lecture for MSc students in Biotechnology, Aarhus University 17 May 2018, “Startups – from failure to success and kidney disease to neuropathic pain”.

Oral Presentation: Marzia Malcangio, Translational Pain Research Symposium, Duke Kunshan University, China 21-23 June 2017. Title: Neuroimmue interactions in the initiation of osteoarthritis pain. Kunshan

Oral presentation: Anders Nykjaer, NGF meeting 2016, April 17-20, Monterey, US

MUW press release on Patch-seq (Nat. Biotech., 2016),

MUW press release on neuronal diversity in the hypothalamus (Nat. Neurosci., 2017),

INSERM press release : Mitochondria are necessary to memory, Paris, 21/11/2016

INSERM press release related to the paper: Soria-Gómez E, Busquets-Garcia A, Hu F, Mehidi A, Cannich A, Roux L, Louit I, Alonso L, Wiesner T, Georges F, Verrier D, Vincent P, Ferreira G, Luo M, Marsicano G. Habenular CB1 Receptors Control the Expression of Aversive Memories. Neuron. 2015 Oct 21

MUW press release related to the publication: Romanov RA, Alpár A, Zhang MD, Zeisel A, Calas A, Landry M, Fuszard M, Shirran SL, Schnell R, Dobolyi A, Oláh M, Spence L, Mulder J, Martens H, Palkovits M, Uhlen M, Sitte HH, Botting CH, Wagner L, Linnarsson S, Hökfelt T, Harkany T. A secretagogin locus of the mammalian hypothalamus controls stress hormone release, EMBO J. 2014 Nov 27. and

At page 73 of the Platinum magazine on the “Research and Innovation” Section, an article about the PAINCAGE project illustrated by the Project Coordinator, prof. Antonino Cattaneo from SNS

INSERM Interview for the national TV reportage “Dossier Tabou: et si on legalisait le cannabis en France” (M6), 27/03/2017

Simona Capsoni (SNS) has signed an agreement with Bentham Publishers to edit 5 ebooks on pain. The first ebook, entitled, Neurotrophins and pain: Relevance to human conditions” is due for late autumn.


Antonino Cattaneo (SNS) was invited at the Pain Mechanisms and Therapeutics Conference, Taormina 5-10 June, 2016, to present an oral communication on: Targeting NGF and TrkA to control neuropathic pain: long lasting effect of an anti-NGF and anti-TrkA antibodies in Chronic Constriction Injury mouse model” by Antonino Cattaneo.


Interesting article and video describing Sara Jager’s (PhD Student in Christian Vaegter’s Lab, AU) PhD project concerning the Neuropathic Pain Treatment

On May 2015 EBRI was present at  Gordon Conference “Cannabinoid Function in the CNS”-Il Ciocco, Lucca, Italy

Paincage Symposium – Italian Society for Neuroscience Meeting: 

Silvia Marinelli from European Brain Research Institute (Italy), Anders Nykjaer from Aarhus University (Denmark) and Simona Capsoni from Scuola Normale Superiore (Italy) held a Symposium, related to the PAINCAGE project, at the XVI Congress of the Italian Society for Neuroscience (8-11 October 2015, Cagliari) on Cannabinoid and NGF and Chronic pain.

Bimodal regulation of GABAergic signalling by cortical cannabinoid type 2 receptors” (EBRI) at 7th European Workshop on Cannabinoid Research, September 2015, Sestri Levante, Italy. 


INSERM also presented data on mitochondrial cannabinoid receptors at the 7th European Workshop on Cannabinoid Research, September 2015, Sestri Levante, Italy.

Partner INSERM reported the following additional conferences and talks in which work co-funded by PAINCAGE was presented:

  • Organisation and talk at “MitoBrain, Conference on mitochondria and the brain” (Bordeaux, 1-3/10/2014)
  • Invitation and talk at the Annual Meeting of the Swiss Society of Neuroscience (Fribourg, 23/01/2015)
  • Invitation and talk at the University of Calgary (Canada), 15/06/2015
  • Invitation and talk at the University of Montreal (Canada), 20/06/2015
  • Invitation and talk at the University of Lausanne (Switzerland), 03/09/2015
  • Invitation and talk at the mini-symposium “Brain Metabolism” in Munich (Germany), 21/12/2015
  • Invitation and talk at Yale University (USA), 06/06/2016
  • Invitation and talk at the symposium “Brain Bioenergetics” in Lausanne (Switzerland), 22-23/06/2016
  • Invitation and talk at the symposium “Stress, Mitochondria, and Brain Function” at the 4th ISPNE Meeting, Miami (USA), 8-11/09/2016
  • Invitation and talk at IIT (Genova, Italy), 29/09/2016
  • Invitation and talk at the symposium “Cannabinoid Pharmacology” in Bern (Switzerland), 10/10/2016
  • Invitation and talk at Columbia University (New York, USA), 10/11/2016
  • Invitation and talk at the symposium “Cannabis in Medicine”, Yale (USA) 12/11/2016
  • Invitation and talk at University of Basque Country (Bilbao, Spain), 15/12/2016
  • Invitation and talk at  University of Salamanca (Spain), 21/04/2017
  • Invitation and talk at the meeting “Meetochondrie”, Hossegor (France), 17/05/2017
  • Invitation and talk at the symposium “Mitochondria and Brain Functions”, at the Meeting of the French Society of Neuroscience (NeuroFrance 2017), Bordeaux (France), 19/05/2017

Interview to Juan Carlos Arevalo from the Universidad de Salamanca, “Investigación sobre el dolor crónico y neurotrofinas” – USAL TV, Salamanca, Spain, 29 May 2014 –

 Levicept announces Paincage project Financing on his website: