On June 23 to 26 2018, the Paincage partner Juan Carlos Arevalo (USAL) organized in Salamanca the international conference on Neurotrophic Factors, the international NGF meetings held every two years. This is the most important meeting worldwide on NGF and neurotrophins, a forum that periodically calls together the most eminent scholars and scientist in the field. In the meeting (http://www.ngfmeetings.com/2018-meeting1.html), two out of nine sessions were dedicated to “Pain, Neurotrophic Factors and Therapies”, and different members of the Paincage consortium were invited speakers and presented their work to the wider community (http://www.ngfmeetings.com/scientific-program.html): Silva Lisa (from Juan Carlos Arevalo lab at USAL), Anders Nikjaer (AU), Antonino Cattaneo (SNS), Simona Capsoni (SNS). Patrick Ernfors from Karolinska Institute in Stockholm reported results performed in collaboration with Tibor Harkany (MUW). In the meeting Mark Brown, the Clinical Leader of the Tanezumab anti NGF program at Pfizer, reported on the progress of anti NGF clinical trials, after the clinical holds by FDA. This meeting was a very good occasion to present some of the Paincage results to the most relevant scientific community.
LINK to the Web page of the meeting: http://www.ngfmeetings.com/2018-meeting1.html
A poster was presented by EBRI: Cerna R, Fiori E, D’Onofrio M,Brandi R, Arisi I, Malerba F, La Regina F, Turturro S, Marinelli S, Vacca V, Pavone F, Cattaneo A, “Long lasting analgesic effect of anti-NGF and anti-TrkA antibodies in neuropathic pain model”
A poster was presented by EBRI on WP4 outcomes: D’Onofrio M, Fiori E, Brandi R, Arisi I, Malerba F, La Regina F, Cerna R, Turturro S, Marinelli S, Vacca V, Pavone F, Cattaneo A. “Targeting NGF and TrkA to control neuropathic pain: long lasting analgesic effect of anti-NGF and anti-TrkA antibodies in Chronic Constriction Injury mouse model”.
A poster was presented by KCL-USAL: Joao Sousa-Valente; Laura Calvo; Juan Carlos, Arevalo; Marzia Malcangio, “TrkA signalling is critical for the initiation of osteoarthritis pain in the monoiodoacetate model”
A poster on HSAN V mice was presented by SNS on WP3 outcomes: G. Testa, L. Pancrazi, M. Ceci, C. Morelli, M. Fabbri, M. Costa, P. Heppenstall, A. Cattaneo, S. Capsoni. Phenotypic characterization of a mouse model of Hereditary Sensory and Autonomic Neuropathy type V: new central aspects of feeling pain. Abstract n. 525.10
Poster was presented by Ivan Arisi (EBRI). Arisi I, D’Onofrio M, Fiori E, Brandi R, Malerba F, La Regina F, Cerna R, Giordano M, Di Battista L, Turturro S, Marinelli S, Vacca V, Pavone F, Cattaneo A. “Targeting NGF and TrkA to control neuropathic pain: a transcriptomic and behavioural study on long lasting analgesic effect of anti-NGF and anti-TrkA antibodies in Chronic Constriction Injury mouse model”.
The poster on “Behavioural and immunohistochemical characterisation of TrkA knock-in mice in the monoiodoacetate model of osteoarthritis” presented by the PAINCAGE partners Joao Sousa-Valente and Marzia Malcangio from the King’s College London and Laura Calvo and Juan Carlos Arevalo from the Universidad de Salamanca, won the first prize at the 13th IASP Research symposium:”Bridging the gaps between pain research and osteoarthritis research” – Stockholm, 17-19th September 2015.
A Poster was presented by SNS on WP3 outcomes: Testa G, Pancrazi L, Capsoni S, Costa M, Cattaneo A. “Towards an NGF-based therapy for Hereditary Sensory and Autonomic Neuropathies IV and V”. XVIII Convention Telethon, 9-11/03/2015, Riva del Garda (TN), Italy
At next IASP in Boston Marzia Malcangio will give a talk based on on the PAICAGE data – Proposal Title: The role of NGF, immune cells and cytokines in arthritic pain
Speaker(s) Marzia Malcangio, PhD – Professor of Neuropharmacology, King’s College London (Role: Session organizer); Camilla Svensson, PhD – Assistant Professor, Karolinska Institute (Role: Speaker): Hans-Georg Schaible, MD – Professor of Physiology, University of Jena (Role: Speaker)- Marzia Malcangio Talk Title will be: Role of mast cells in mediating NGF nociception in the MIA model
Oral Presentation: Marzia Malcangio, Translational Pain Research Symposium, Duke Kunshan University, China 21-23 June 2017. Title: Neuroimmue interactions in the initiation of osteoarthritis pain. Kunshan
Oral presentation: Anders Nykjaer, NGF meeting 2016, April 17-20, Monterey, US http://www.ngfmeetings.com/scientific-program.html
MUW press release on Patch-seq (Nat. Biotech., 2016), https://www.meduniwien.ac.at/web/en/about-us/news/detailsite/?tx_news_pi1%5Bnews%5D=3191&tx_news_pi1%5Bcontroller%5D=News&tx_news_pi1%5Baction%5D=detail&cHash=81fcbe96662d9896ccf3f46ab8a97166
MUW press release on neuronal diversity in the hypothalamus (Nat. Neurosci., 2017), https://www.meduniwien.ac.at/web/en/about-us/news/detailseite/2016/news-in-december-2016/charting-a-molecular-map-of-the-brain-a-catalogue-of-dozens-of-new-neuronal-subtypes-in-the-hypothalamus/
INSERM press release : Mitochondria are necessary to memory, Paris, 21/11/2016
INSERM press release related to the paper: Soria-Gómez E, Busquets-Garcia A, Hu F, Mehidi A, Cannich A, Roux L, Louit I, Alonso L, Wiesner T, Georges F, Verrier D, Vincent P, Ferreira G, Luo M, Marsicano G. Habenular CB1 Receptors Control the Expression of Aversive Memories. Neuron. 2015 Oct 21 http://presse.inserm.fr/en/should-i-stay-or-should-i-go-on-the-importance-of-aversive-memories-and-the-endogenous-cannabinoid-system/20775/?add_doc=20775
MUW press release related to the publication: Romanov RA, Alpár A, Zhang MD, Zeisel A, Calas A, Landry M, Fuszard M, Shirran SL, Schnell R, Dobolyi A, Oláh M, Spence L, Mulder J, Martens H, Palkovits M, Uhlen M, Sitte HH, Botting CH, Wagner L, Linnarsson S, Hökfelt T, Harkany T. A secretagogin locus of the mammalian hypothalamus controls stress hormone release, EMBO J. 2014 Nov 27. http://www.meduniwien.ac.at/homepage/1/news-and-topstories/?tx_ttnews%5Btt_news%5D=5302&cHash=217cf5c503a66cf6434b2cf627c08280 and http://ki.se/en/news/secretagogin-triggers-stress-process-in-the-brain
At page 73 of the Platinum magazine on the “Research and Innovation” Section, an article about the PAINCAGE project illustrated by the Project Coordinator, prof. Antonino Cattaneo from SNS
INSERM Interview for the national TV reportage “Dossier Tabou: et si on legalisait le cannabis en France” (M6), 27/03/2017
Simona Capsoni (SNS) has signed an agreement with Bentham Publishers to edit 5 ebooks on pain. The first ebook, entitled, Neurotrophins and pain: Relevance to human conditions” is due for late autumn.
Antonino Cattaneo (SNS) was invited at the Pain Mechanisms and Therapeutics Conference, Taormina 5-10 June, 2016, to present an oral communication on: Targeting NGF and TrkA to control neuropathic pain: long lasting effect of an anti-NGF and anti-TrkA antibodies in Chronic Constriction Injury mouse model” by Antonino Cattaneo.
On May 2015 EBRI was present at Gordon Conference “Cannabinoid Function in the CNS”-Il Ciocco, Lucca, Italy
Silvia Marinelli from European Brain Research Institute (Italy), Anders Nykjaer from Aarhus University (Denmark) and Simona Capsoni from Scuola Normale Superiore (Italy) held a Symposium, related to the PAINCAGE project, at the XVI Congress of the Italian Society for Neuroscience (8-11 October 2015, Cagliari) on Cannabinoid and NGF and Chronic pain.
INSERM also presented data on mitochondrial cannabinoid receptors at the 7th European Workshop on Cannabinoid Research, September 2015, Sestri Levante, Italy.
Partner INSERM reported the following additional conferences and talks in which work co-funded by PAINCAGE was presented:
Interview to Juan Carlos Arevalo from the Universidad de Salamanca, “Investigación sobre el dolor crónico y neurotrofinas” – USAL TV, Salamanca, Spain, 29 May 2014 – http://tv.usal.es/videos/1591/investigaci%C3%B3n-sobre-el-dolor-cr%C3%B3nico-y-neurotrofinas.