The NGF System and its interplay with endocannabinoid signalling, from peripheral sensory terminals to the brain: new targets for the development of next generation drugs for neuropathic pain

Submitted (last update 26/06/2018)

Manuscript submitted (Nature Neuroscience)
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Zhang MD, Tortoriello G, Hsueh B, Tomer R, Ye L, Mitsios N, Borgius L, Grant G, Kiehn O, Watanabe M, Uhlén M, Mulder J, Deisseroth K, Harkany T* and Hökfelt TGM*. Neuronal calcium-binding proteins 1/2 localize to dorsal root ganglia and excitatory spinal neurons and are regulated by nerve injury. Proc Natl Acad Sci USA (2014) 111:1149-1158.

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The above references that had appeared in the European Journal of Neuroscience are part of a “Special Issue” whose concept and editorial work were performed by T. Harkany and A. Cattaneo, as part of the PAINCAGE consortium’s pledge to disseminate contemporary concepts on endocannabinoid and/or neurotrophin signaling in sensory neurons and ascending spinal networks.

*Yu, T., *Calvo, L., Anta, B., López-Benito, S., López-Bellido, R., Vicente-Garcia, C., Tessarollo, L., Rodríguez, R.E. and Arévalo, J.C. 2014. In vivo regulation of NGF-mediated functions by Nedd4-2 ubiquitination of TrkA. J. Neurosci. 34: 6098-6106. *Equal contribution